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Generally , Morphine is a pain medication of the opiate type which is found naturally in a number of plants and animals. It acts directly on the central nervous system (CNS) to decrease the feeling of pain. It can be taken for both acute pain and chronic pain. Morphine is frequently used for pain from myocardial infarction and during labour.

It can be given by mouth, by injection into a muscle, by injecting under the skin, intravenously, into the space around the spinal cord, or rectally. Maximum effect is around 20 min when given intravenously and 60 min when given by mouth while the duration of effect is between three and seven hours. Long-acting formulations also exist.

Morphine, formerly also called morphia, is an opiate that is found naturally in opium, a dark brown resin produced by drying the latex of opium poppies (Papaver somniferum). It is mainly used as an analgesic (pain medication). There are numerous methods used to administer morphine: orally; administered under the tongue; via inhalation; injection into a vein, injection into a muscle, injection under the skin, or injection into the spinal cord area; transdermal; or via administered into the rectal canal suppository. It acts directly on the central nervous system (CNS) to induce analgesia and alter perception and emotional response to pain. Physical and psychological dependence and tolerance may develop with repeated administration. It can be taken for both acute pain and chronic pain and is frequently used for pain from myocardial infarction, kidney stones, and during labor. Its maximum effect is reached after about 20 minutes when administered intravenously and 60 minutes when administered by mouth, while the duration of its effect is 3–7 hours. Long-acting formulations of morphine are sold under the brand names MS Contin and Kadian, among others. Generic long-acting formulations are also available. 

Common side effects of morphine include drowsiness, euphoria, nausea, dizziness, sweating, and constipation. Potentially serious side effects of morphine include decreased respiratory effort, vomiting, and low blood pressure.Morphine is highly addictive and prone to abuse.If one’s dose is reduced after long-term use, opioid withdrawal symptoms may occur.Caution is advised for the use of morphine during pregnancy or breastfeeding, as it may affect the health of the baby.

Morphine was first isolated in 1804 by German pharmacist Friedrich Sertürner.This is believed to be the first isolation of a medicinal alkaloid from a plant.Merck began marketing it commercially in 1827.Morphine was more widely used after the invention of the hypodermic syringe in 1853–1855. Sertürner originally named the substance morphium, after the Greek god of dreams, Morpheus, as it has a tendency to cause sleep.

The primary source of morphine is isolation from poppy straw of the opium poppy. In 2013, approximately 523 tons of morphine were produced. Approximately 45 tons were used directly for pain, an increase of 400% over the last twenty years.Most use for this purpose was in the developed world.About 70% of morphine is used to make other opioids such as hydromorphone, oxymorphone, and heroin.It is a Schedule II drug in the United States,Class A in the United Kingdom, and Schedule I in Canada. It is on the World Health Organization’s List of Essential Medicines.  In 2022, it was the 139th most commonly prescribed medication in the United States, with more than 4 million prescriptions.  It is available as a generic medication.

Morphine is used primarily to treat both acute and chronic severe pain. Its duration of analgesia is about three to seven hours.Side effects of nausea and constipation are rarely severe enough to warrant stopping treatment.

It is used for pain due to myocardial infarction and for labor pains.However, concerns exist that morphine may increase mortality in the event of non ST elevation myocardial infarction.

Morphine has also traditionally been used in the treatment of acute pulmonary edema. However, a 2006 review found little evidence to support this practice.

Morphine is beneficial in reducing the symptom of shortness of breath due to both cancer and non-cancer causes. In the setting of breathlessness at rest or on minimal exertion from conditions such as advanced cancer or end-stage cardiorespiratory diseases, regular, low-dose sustained-release morphine significantly reduces breathlessness safely, with its benefits maintained over time.

Morphine is also available as a slow-release formulation for opiate substitution therapy (OST) in Austria, Germany, Bulgaria, Slovenia, and Canada for persons with opioid addiction who cannot tolerate either methadone or buprenorphine.^[37]

• 
  Two capsules (5 mg & 10 mg) of morphine sulfate extended-release
• 
  1 milliliter ampoule containing 10 mg of morphine

Relative contraindications to morphine include:

• respiratory depression when appropriate equipment is not available.
• Although it has previously been thought that morphine was contraindicated in acute pancreatitis, a review of the literature shows no evidence for this.

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